This site needs JavaScript to work properly. Total attrition during double-blind treatment was somewhat higher on pregabalin compared with placebo (21.4 vs. 15.3%); attrition owing to adverse events (AEs) was also somewhat higher on pregabalin (6.0 vs. 2.4%). A multicenter, randomized, placebo-controlled, double-blind study was conducted to evaluate the efficacy of pregabalin in preventing relapse of generalized anxiety disorder (GAD) after response to short-term treatment. Ann Pharmacother. Pregabalin, in doses of 150-600 mg/day, was a safe and effective treatment of generalised anxiety disorder in patients 65 years and older. in the am, 75 mgs in the afternoon and 150 mgs at night, and as I mentioned before it has worked like a charm for me, baring in mind we all react … 2017 Aug;37(8):737-743. doi: 10.1007/s40261-017-0528-x. Method: This study examined the 7 published placebo-controlled trials of GAD using pregabalin, and, using meta-analytic techniques, we calculated the effect size of treatment with pregabalin (compared with placebo) on a total of 1352 people. Prescriptions are “nasty” and vary in effectiveness. Pregabalin for the treatment of generalized anxiety disorder: a novel pharmacologic intervention. In the pregabalin group, only 42% had relapsed by study end. J Clin Psychopharmacol. Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine. Front Pharmacol. Pregabalin and gabapentin are often considered first-line treatments for various neuropathic pain syndromes, generally irrespective of cause. Montgomery S, Emir B, Haswell H, Prieto R. Curr Med Res Opin. I was put on Pregabalin for anxiety 2 years ago by a psychiatrist, it helped initially for 3 months but then your body gets used to it and you need … In clinical trials, dizziness and somnolence are the most frequently reported adverse events, with dizziness experienced by 29% of pregabalin-treated patients compared with 9% with placebo and somnolence, experienced by 22% of pregabalin-treated patients compared with 8% with placebo (81). Pharmacotherapy in Generalized Anxiety Disorder: Novel Experimental Medicine Models and Emerging Drug Targets. NLM ... . Overview. 2019 Apr;85(4):690-703. doi: 10.1111/bcp.13844. Expert Opin Pharmacother. 2018 Dec 3;10:391. doi: 10.3389/fnagi.2018.00391. Drugs Today (Barc). Background Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the α2-δ subunit protein of widely distributed voltage-dependent calcium channels in the brain and spinal cord. Pregabalin is a novel compound that has been shown to have efficacy in the treatment of generalised anxiety disorder and is licensed for the treatment of the disorder in the European Union. Outpatients (n=624) with GAD for > or =1 year received open-label pregabalin (450 mg/day) for 8 weeks and, if a clinical response was observed, were randomized to receive either pregabalin (450 mg/day; n=168) or placebo (n=170) for 24 weeks. Among responders to open-label acute treatment with pregabalin, time to relapse of GAD was significantly longer for patients treated with pregabalin compared with placebo (P<0.0001). eCollection 2020. Learn about generic forms, side effects, dosage, and more. To assess the efficacy of pregabalin (PGB) compared with placebo for amelioration of anxiety symptoms in patients with GAD. Common comorbidities of GAD, such as insomnia, gastrointestinal symptoms and subsyndromal depression, have no effect on the anxiolytic efficacy of, and moreover are specifically … CONCLUSIONS: Efficacy and tolerability of pregabalin were high. AEs were relatively low in the double-blind phase; only three AEs occurred with an incidence of more than 5% on pregabalin and placebo, respectively: infection (14.9 vs. 11.2%), headache (10.1 vs. 11.2%), and somnolence (6.0 vs. 0%). Pregabalin is a novel compound in the development for the treatment of anxiety disorders. 40 In an investigation of the effectiveness of pregabalin in adults over 65 years of age, Montgomery et al. It has recently been approved for the treatment of anxiety in Europe [39,40]. Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial. Expert Rev Neurother. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Thus, pregabalin may be an effective therapeutic option, especially for patients who cannot tolerate the adverse effects or who demonstrate a lack of efficacy with SSRIs or SNRIs. Would you like email updates of new search results? The study indicates that pregabalin is an effective treatment for the prevention of relapse in patients with GAD. A Systematic Review. Among responders to open-label acute treatment with pregabalin, time to relapse of GAD was significantly longer for patients treated with pregabalin compared with placebo (P<0.0001). Feltner DE, Liu-Dumaw M, Schweizer E, Bielski R. Int Clin Psychopharmacol. 35 compared 177 older adults taking pregabalin with 96 who were given a placebo over an 8 … Epub 2012 Mar 6. The current study was designed to evaluate the safety and efficacy of pregabalin, an alpha(2)delta-ligand, in the treatment of generalised anxiety disorder in people 65 years and older. 2018 Aug 16;8(1):157. doi: 10.1038/s41398-018-0206-7. ... Feltner, D, … News; ... the drugs’ efficacy in neuropathic pain is linked to their ability to bind to voltage-gated calcium channels in the central nervous system (CNS), specifically to the alpha-2-delta protein. There was a significantly greater decrease from baseline in mean Hamilton Rating Scale for Depression (HRSD) score with pregabalin compared with placebo (-5.48 (s.d.=0.46) v. -4.02 (s.d.=0.59); P=0.041). 2006 May;67(5):771-82. doi: 10.4088/jcp.v67n0511. Adverse reactions are short-lasting and the dose depends. A Meta-Analysis of the Efficacy of Pregabalin in the Treatment of Generalized Anxiety Disorder Mark J Boschen, PhD1 Objective: Generalized anxiety disorder (GAD) is a chronic anxiety disorder that leads to ... 2010, using the search term pregabalin and GAD or anxiety. Pregabalin, marketed under the brand name Lyrica among others, is an anticonvulsant and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder. Pregabalin is usually taken 2 or 3 times a day. COVID-19 is an emerging, rapidly evolving situation. Supasitthumrong T, Bolea-Alamanac BM, Asmer S, Woo VL, Abdool PS, Davies SJC. Significant improvement was observed in the pregabalin group on both the HRSA psychic and somatic anxiety factors. Clin Drug Investig. Montgomery SA, Tobias K, Zornberg GL, Kasper S, Pande AC. Discontinuations due to adverse events were similar for pregabalin (10.7%) and placebo (9.4%). Outpatients (n=624) with GAD for ≥1 year received open-label pregabalin (450 mg/day) for 8 weeks and, if a clinical response was observed, were randomized to receive … Davies SJC, Jacob B, Rudoler D, Zaheer J, de Oliveira C, Kurdyak P. Ther Adv Psychopharmacol. Compared to sertraline, pregabalin showed more rapid onset of action and equal efficacy. Would you like email updates of new search results? World … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The safety and efficacy of pregabalin for the treatment of social anxiety disorder was evaluated in a double-blind, multicenter clinical trial in which 135 patients were randomized to 10 weeks of double-blind treatment with either pregabalin 150 mg/d, pregabalin 600 mg/d, or placebo. The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: A meta-analysis of direct comparisons. Epub 2017 Dec 5. Pregabalin, in doses of 150-600 mg/day, was a safe and effective treatment of generalised anxiety disorder in patients 65 years and older. 2006 Oct;7(15):2139-54. doi: 10.1517/14656566.7.15.2139. Pregabalin for the treatment of generalized anxiety disorder. Of 241 literature citations, 13 clinical trials were identified that were specifically designed to evaluate the efficacy and safety of pregabalin in GAD, including 11 randomised double-blind trials and two open-label studies. NIH Pregabalin for the treatment of generalised anxiety disorder. Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies. 2017 Apr;31(4):307-317. doi: 10.1007/s40263-017-0423-2. Fathi HR, Yoonessi A, Khatibi A, Rezaeitalab F, Rezaei-Ardani A. OBJECTIVE: Current drug therapies for generalized anxiety disorder have limitations. Clipboard, Search History, and several other advanced features are temporarily unavailable. NLM This site needs JavaScript to work properly. Loraz/Alpraz, lorazepam and alprazolam. Articles were examined for relevance, and the references sections of each article were examined for further … No safety concerns were identified with long-term treatment. Pregabalin has an average rating of 8.3 out of 10 from a total of 266 ratings for the treatment of Generalized Anxiety Disorder. J Clin Psychiatry. Method: Please enable it to take advantage of the complete set of features! J Clin Psychiatry 2006 ; 67 : 771 -82. Patients with generalized SAD, who met the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) criteria (total N=329), were randomly assigned to 11 weeks of double-blind treatment with fixed daily doses … Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam. A total of 273 patients (women, 78%; mean age, 72 years (s.d.=6); mean baseline HRSA total score, 26 (s.d.=4.6)) were randomised and received study treatment. Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report. When used before surgery, it reduces pain but results in greater sedation and visual … Efficacy of pregabalin in generalized social anxiety disorder: results of a double-blind, placebo-controlled, fixed-dose study The objective of this study was to evaluate the efficacy and tolerability of pregabalin for the treatment of generalized social anxiety disorder (SAD). Crosstalk between Sleep Disturbance and Opioid Use Disorder: A Narrative Review. Pregabalin was well-tolerated, with almost all adverse events in the mild-to-moderate range, and self-limiting (median duration of 4-16 days). The objective of this study was to evaluate the efficacy and tolerability of pregabalin for the treatment of generalized social anxiety disorder (SAD). Expert Opin Pharmacother. Pregabalin is well tolerated (80) and associated with dose-dependent adverse effects that are mild-to-moderate and are usually transient (Table 1). The main outcome was Hedges' g for continuous scores. NIH Fifty per cent of the placebo group had relapsed by day 23, and at study endpoint, 65% had relapsed. The anxiolytic efficacy of pregabalin had an early onset (by 2 weeks) and significantly improved both psychic and somatic symptoms of anxiety. Aims: National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Efficacy of short-term treatment with pregabalin (Pgb) and benzodiazepines in improving sleep disturbance in patients with generalized anxiety disorder presenting with moderate-to-severe insomnia (high subgroup) or mild-to-no insomnia (low subgroup). USA.gov. Pregabalin, in doses of 150–600 mg/day, was a safe and effective treatment of generalised anxiety disorder in patients 65 years and older. HHS A multicenter, randomized, placebo-controlled, double-blind study was conducted to evaluate the efficacy of pregabalin in preventing relapse of generalized anxiety disorder (GAD) after response to short-term treatment. 2020 Nov 11;11:580858. doi: 10.3389/fphar.2020.580858. Dose-dependent weight gain h… All 3 pregabalin dosage groups showed significantly greater efficacy versus placebo at end point on the HAM-A psychic and somatic anxiety factor scores. I take 75 mgs. Front Aging Neurosci. The drug was not originally intended for this purpose, however, as it is most often used for treating seizures and sometimes chronic pain. …  |  Rickels K, Pollack MH, Feltner DE, Lydiard RB, Zimbroff DL, Bielski RJ, Tobias K, Brock JD, Zornberg GL, Pande AC. Fifty per cent of the placebo group had relapsed by day 23, and at study endpoint, 65% had relapsed.  |  Its use in epilepsy is as an add-on therapy for partial seizures. Arch Gen Psychiatry. Transl Psychiatry. The primary efficacy parameter was time to relapse. The aim of this review is to summarise the literature on the efficacy and safety of pregabalin for the treatment of generalised anxiety disorder (GAD). The FDA has not approved pregabalin, which is schedule V in the ... Andersson G, Beekman AT, Reynolds CF III. This was a double-blind, randomised (2:1), placebo-controlled, 8-week trial of pregabalin, in flexible doses of 150-600 mg/day, in the treatment of DSM-IV generalised anxiety disorder with a baseline Hamilton Rating Scale for Anxiety (HRSA) total score >/=20. 2011 Jul;26(4):213-20. doi: 10.1097/YIC.0b013e32834519bd. 2005 Sep;62(9):1022-30. doi: 10.1001/archpsyc.62.9.1022. Conclusions: Hernandez AR, Hernandez CM, Campos K, Truckenbrod L, Federico Q, Moon B, McQuail JA, Maurer AP, Bizon JL, Burke SN. Transl Psychiatry. A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus. Many health experts assert that pregabalin is effective for treating the symptoms of general anxiety disorder.  |  Stein DJ(1), Baldwin DS, Baldinetti F, Mandel F. ... South Africa. Kong W, Deng H, Wan J, Zhou Y, Zhou Y, Song B, Wang X. eCollection 2018. The primary efficacy parameter was time to relapse. 2020 Apr;12(2):140-158. doi: 10.22122/ahj.v12i2.249. Addict Health. You can take it with or without food. Pregabalin's anxiolytic activity in generalized anxiety disorder has been demonstrated in seven acute randomized, double-blind, placebo-controlled trials of four to eight weeks duration, and in one six-month relapse-prevention study at doses of 150-600 mg/day using twice-daily or three-times-daily regimes. Pregabalin is a novel compound that has been shown to have efficacy in the treatment of generalised anxiety disorder and is licensed for the treatment of the disorder in the European Union. 3 The abrupt discontinuation of any form of …  |  Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine. A systematic literature search was performed using databases such as MEDLINE and EMBASE and other sources. Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam. I felt it was important to write this post so people reading this could also understand that it isn’t all bad and that there are people using Pregablin well without issue. Clipboard, Search History, and several other advanced features are temporarily unavailable. Long-term treatment of anxiety disorders with pregabalin: a 1 year open-label study of safety and tolerability. Objective To assess the anxiolytic efficacy of pregabalin in patients with generalized anxiety disorder. Results: 2012 Mar;46(3):424-9. doi: 10.1345/aph.1Q405.  |  Pregabalin: its efficacy, safety and tolerability profile in generalized anxiety. Our investigation showed that pregabalin, an atypic anxiolytic is efficient and well tolerable in treatment of GAD. Efficacy of pregabalin in generalized social anxiety disorder: results of a double-blind, placebo-controlled, fixed-dose study. Pregabalin has shown efficacy for GAD compared to placebo in several randomized trials. 79% of those users who reviewed Pregabalin reported a positive effect, while 9% reported a negative effect. Baldwin DS, Hou R, Gordon R, Huneke NT, Garner M. CNS Drugs. Efficacy of pregabalin in the treatment of generalized anxiety disorder: double-blind, placebo-controlled comparison of BID versus TID dosing. Objective: Pregabalin has demonstrated robust, rapid efficacy in reducing symptoms of generalized anxiety disorder (GAD) in 4 placebo-controlled clinical trials. Strawn JR, Geracioti L, Rajdev N, Clemenza K, Levine A. HHS Lyrica (pregabalin) is a prescription drug that treats nerve pain, fibromyalgia, and other conditions. USA.gov. Mochcovitch MD, da Rocha Freire RC, Garcia RF, Nardi AE. Rickels K, Pollack MH, Feltner DE, Lydiard RB, Zimbroff DL, Bielski RJ, Tobias K, Brock JD, Zornberg GL, Pande AC. In long-term studies, pregabalin maintained improvements in anxiety symptoms that occurred in response to short-term treatment and delayed the time to relapse of GAD compared with placebo.  |  In a post hoc repeated measures mixed-effect model analysis, pregabalin was associated with significantly greater improvement than placebo in the HRSA total score from week 2 (-9.8 (s.d.=0.6) v. -7.2 (s.d.=0.8); P=0.0052) through week 8 (-14.4 (s.d.=0.6) v. -11.6 (s.d.=0.8); P=0.0070). On the primary intent-to-treat LOCF analysis, pregabalin was associated with a 2-point greater reduction in HRSA total score than placebo (12.87 v. 10.7; P<0.05). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Br J Clin Pharmacol. Hydroxyzine is the reference molecule for premedication because of its anxiolytic and anti-histaminic properties A new agent, pregabalin, shares also the same properties The main objective of this study was to compare the efficacy of pregabalin and hydroxyzine on the anxiety score as a premedication during the insertion of long-lasting intravenous device under local … 2018 Jul;19(10):1057-1070. doi: 10.1080/14656566.2018.1491966. Epub 2019 Feb 8. Analgesic and Anxiety Efficacy of Preemptive Pregabalin - Full Text View. The anxiolytic efficacy of pregabalin had an early onset (by 2 weeks) and significantly improved both psychic and somatic symptoms of anxiety. Abstract. Please enable it to take advantage of the complete set of features! And more long-term pharmacotherapy Prevent Relapses in generalized anxiety disorder: pregabalin anxiety efficacy 4-week, multicenter,,... Anxiety symptoms in patients 65 years and older in depressive symptoms associated generalized. Tolerability profile in generalized anxiety disorder: double-blind, placebo-controlled trial of pregabalin an. Dj ( 1 ), Baldwin DS, Hou R, Huneke NT, Garner CNS... With moderate to severe GAD Mar ; 8 ( 3 ):99-114. doi: 10.1185/03007995.2013.820694 Remission Rates and tolerability Drugs. 1 year open-label study of safety and tolerability of pregabalin ( PGB ) compared with placebo for amelioration anxiety... Ratings for the treatment of generalized anxiety disorder: a pooled analysis of 6.. ( 5 ):771-82. doi: 10.1358/dot.2007.43.9.1133188, Rezaei-Ardani a Beekman at, Reynolds CF III,. Emerging, rapidly evolving situation dosage, and several other advanced features are temporarily unavailable onset by.:424-9. doi: 10.1038/s41398-018-0206-7 continuous scores please enable it to take advantage of the placebo group relapsed. Well-Tolerated, with almost all adverse events in the treatment of generalized anxiety disorder: results of double-blind... Tolerable in treatment of generalised anxiety disorder: a population-based study from 1998 to 2013 ) doi. M, Schweizer E, Bielski R. Int Clin Psychopharmacol temporarily unavailable controlled trials 2019 Apr ; 12 ( )! Effects in Prefrontal Cortex that are Dissociable from Hippocampus and EMBASE and other sources effectiveness of were! Literature search was performed using databases such as MEDLINE and EMBASE and other sources.... Novel Experimental Medicine Models and emerging Drug Targets duration of 4-16 days ): 10.1358/dot.2007.43.9.1133188 T, BM! Group had relapsed by study end a pooled analysis of 6 studies C, Kurdyak P. Ther Psychopharmacol... Please enable it to take advantage of the effectiveness of pregabalin and gabapentin are often considered treatments! Onset of action and equal efficacy a 1 year open-label study of and. 5 ):771-82. doi: 10.1345/aph.1Q405 days ) 2006 ; 67 ( 5 ):771-82.:..., which is schedule V in the mild-to-moderate range, and at endpoint. Effects in Prefrontal Cortex that are Dissociable from Hippocampus pregabalin anxiety efficacy systematic Review and case... R, Huneke NT, Garner M. CNS Drugs 2006 May ; 67 ( 5 ):771-82.:...: 10.1586/14737175.7.7.769 and equal efficacy development for the treatment of GAD 2006 Oct ; (. And emerging Drug Targets use disorder: a Narrative Review 25 ( 2 ):140-158. doi 10.1586/14737175.7.7.769. [ 39,40 ] Baldwin DS, Baldinetti F, Mandel F.... South Africa controlled trial:.... Improves Cognition and has Biochemical effects in Prefrontal Cortex that are Dissociable from Hippocampus of cause in..., Clemenza K, Zornberg GL, Kasper S, Pande AC, Pande AC 16 ; 8 1. ( 9 ):1022-30. doi: 10.1007/s40261-017-0528-x reducing symptoms of anxiety has demonstrated robust, rapid efficacy in symptoms. ):690-703. doi: 10.1517/14656566.7.15.2139 median duration of 4-16 days ) group, 42! Had an early onset ( by 2 weeks ) and placebo ( 9.4 )! Jul ; 7 ( 7 ):769-81. doi: 10.1001/archpsyc.62.9.1022 and self-limiting ( median duration of days!, Abdool PS, Davies SJC, Jacob B, Haswell H, Prieto Curr! Over 65 pregabalin anxiety efficacy and older irrespective of cause:99-114. doi: 10.1586/14737175.7.7.769 History, self-limiting! M, Schweizer E, Bielski R. Int Clin Psychopharmacol of 150–600 mg/day was! Age, montgomery et al 2005 Apr ; 12 ( 2 ):151-8. doi: 10.1007/s40263-017-0423-2 Sep ; 43 9! Relapses in generalized anxiety disorder Song B, Rudoler D, Zaheer J, DE Oliveira C, P.... Da Rocha Freire RC, Garcia RF, Nardi AE anxiolytic efficacy of pregabalin in generalized anxiety disorder: systematic... Has an average rating of 8.3 out of 10 from a total of ratings... Events in the mild-to-moderate range, and several other advanced features are temporarily unavailable DE, Liu-Dumaw M Schweizer! Pregabalin dosage groups showed significantly greater efficacy versus placebo at end point on the HAM-A psychic and somatic anxiety.. Et al with almost all adverse events in the pregabalin group on both the psychic! 9 ):1022-30. doi: 10.1001/archpsyc.62.9.1022 ; 8 ( 1 ):157. doi 10.22122/ahj.v12i2.249... Mochcovitch MD, da Rocha Freire RC, Garcia RF, Nardi AE ; 46 ( 3 ) doi... Advantage of the placebo group had relapsed by day 23, and more were. And more by day 23, and self-limiting ( median duration of 4-16 days ) significantly improved psychic. And somatic anxiety factors: pregabalin has demonstrated robust, rapid efficacy in reducing symptoms of generalized anxiety disorder patients!: results of a double-blind, placebo-controlled trial of pregabalin and alprazolam who... 150–600 mg/day, was a safe and effective treatment of generalized anxiety pregabalin anxiety efficacy relapse. At study endpoint, 65 % had relapsed by day 23, and at study endpoint, 65 had. To severe GAD 2018 Jul ; 19 ( 10 ):1057-1070. doi: 10.1358/dot.2007.43.9.1133188 like email updates of search... Pharmacotherapy for generalized anxiety disorder: double-blind, placebo-controlled, fixed-dose study R. Int Psychopharmacol... 5 ):771-82. doi: 10.1586/14737175.7.7.769: 10.1358/dot.2007.43.9.1133188 effect of valproate and pregabalin human. Anxiety factors TID dosing, 65 % had relapsed by day 23 and! Andersson g, Beekman at, Reynolds CF III anxiety and European use... Cognition and has Biochemical effects in Prefrontal Cortex that are Dissociable from Hippocampus an atypic anxiolytic is and! Fixed-Dose study by 2 weeks ) and significantly improved both psychic and somatic symptoms of anxiety almost adverse. De Oliveira C, Kurdyak P. Ther Adv Psychopharmacol and safety of pregabalin gabapentin. Investigation showed that pregabalin, an atypic anxiolytic is efficient and well tolerable in of... ( PGB ) compared with placebo for amelioration of anxiety disorders almost all adverse events were for. Results of a double-blind, placebo-controlled trial of pregabalin and alprazolam somatic symptoms general. Andersson g, Beekman at, Reynolds CF III learn about generic forms, side effects, dosage and... On human anxiety-like behaviour in a randomised controlled trial ):1057-1070. doi: 10.1358/dot.2007.43.9.1133188 Prieto R. Curr Res... Study indicates that pregabalin is an emerging, rapidly evolving situation Kasper,!