Abnormal and normal cystoscopic findings correlated with a biopsy‐proven cancer in 13/53 (24.5%) and 14/74 (18.9%) cases, respectively. Fine needle aspiration cytology versus trucut biopsy in the diagnosis of breast cancer: a comparative study Shashirekha C. A., Rahul Singh R.*, Ravikiran H. R., Sreeramulu P. N., Krishna Prasad breast INTRODUCTION Breast cancer is the one of the most researched cancer across the world and new advancements for the treatment Nutritional Support of the Critical Patient, Oxygen & Ventilation During Resuscitation, Treatment of Hyperthermia & Heat-Induced Illness, Reproductive Surgery in Female Asian Pythons, Treatment of Shell Necrosis in Orlitia borneensis, Zoonotic Diseases of Birds, Reptiles, & Fish, Metabolic Causes in Feline Neurologic Diseases, Sedation vs. General Anesthesia for Kitty, Treating Feline Inflammatory Liver Disease, Implications of Nutrition & Dental Health, Nutritional Support for Joint Surgery Patient, Analgesic Tools in Small Animal Anesthesia, Imaging Approaches for Vomiting Dogs & Cats, Liver: One Big Brown Organ in Gray Shades, (Im)Possibilities of Thoracic Ultrasonography, Diagnostic Techniques for Infectious Diseases, Blood Transfusion Transmission of Infectious Diseases, Diabetes Mellitus When Insulin Not Working, Diagnosis & Management of Calcium Disorders, Extracorporeal Blood Purification Techniques, Urolith in Thailand Vs Global Perspective, Emergency Procedures to Save Patients' Lives, Insulin Resistance: Diagnosis & Management, Predisposive, Primary & Perpetuating Causes of Otitis, Reducing Stress for Animals in Veterinary Clinic, Relationship Between Neuter Status & Cancer, Integrating Cancer Care Into General Practice, Cytological Grading for Mast Cell Tumor Aspirates, Epidemiological Analysis of Dog Behaviour Problems, Blood Pressure & Renal Injury from Leishmaniasis, Ultrasonography & Hepatocellular Carcinoma, Incidence of Diabetes in Insured Swedish Cats, Canine PLI & C-Reactive Protein in Dogs with Pancreatitis, Differentiating Orthopedic & Neurologic Disease, Emergency Management of Status Epilepticus, Pathologist Suggested Immunohistochemistry, Alternative Medicine, Homeopathy & Acupuncture, Low Level Laser Therapy & Low Adherent Dressing, Low Level Laser Therapy for Multiple Fractures, Inhumane Culling of Dogs in Response to Rabies, Catestatin Concentrations as Markers for Stress, Androstenone Reduces Leash Pulling & Jumping Up, Maternal-Neonatal Pheromone Added to Cat Litter, Acute Effects of Sildenafil on Ventricular Functions, Balloon Dilatation for Nasopharyngeal Stenosis, Intermittent Hemodialysis in Chronic Kidney Disease, Alacepril vs. Other ACE-Inhibitors in Mitral Regurgitation, Statins in Hyperadrenocorticism/Hyperlipidemia Dog, Carbamazepine and/or Phenytoin in Wistar Rats, Protective Effects of Crocin on Hepatic Steatosis, Various Therapeutic Agents Against Sarcoptic Mange, EDTA Tris & Antibiotics in Chronic Otitis Externa, Melatonin & Niacinamide for Follicular Dysplasia, Acoustic Radiation Force Impulse Elastography, Tetralogy of Fallot with Pulmonary Atresia, Anatomical Differences of Constrictor Snakes, Radiography, CT & 3D Reconstruction of Pelvis, Successful Treatment of Sepsis in a Shark Ray, Treatment of Sepsis in Zebra Bullhead Shark, Fracture Diagnosis of Cougar Lacrimal Bone, Gastrointestinal Parasites of Brazilian Cats, Diagnostics of Canine Parvovirus Infection, DGGR Is Not a Specific Substrate for Pancreatic Lipase, Mutant Allele Frequency of Erythrocyte PK Deficiency, Risk of Introducing Peste Des Petits Ruminants, Struvite RSS Below 1 Predictive of Dissolution, Distribution of MRSP in Small Animal Hospital, Evaluation of a Novel Clinical Tool; Pockit, Glomerulopathies in Dogs with Ehrlichiosis, Inflammatory Cytokines in Visceral Leishmaniasis, Melioidosis Presenting as Localized Osteomyelitis, PCR-Pockit Detection of Canine Parvovirus, Vector-Borne Pathogens in Dogs from Korea, Lafora-Like Inclusion Bodies in Dachshund, Super-Refractory Status Epilepticus in Dog, Neurological Disorders in Companion Animals, Erythropoietin & Pro-Inflammatory Cytokines Levels, Expression of E-Cadherin in Oral Melanoma, Expression of Involucrin in Squamous Cell Carcinoma, Minimal Residual Disease Detection by Heteroduplex PCR, Treatment of Canine Transmissible Venereal Tumor, Management of Canine Ulcerative Keratitis, Transscleral Cyclophotocoagulation for Secondary Glaucoma, Reasons & Risk Factors for Limb Amputation, Fatty Acid Compound & NSAIDs for Osteoarthritis, Adipokines & Cranial Cruciate Ligament Rupture, Vertical Patellar Position in Medial Patellar Luxation, Efficacy of Spray Formulation of Meloxicam, Owner’s Perception About Overweight & Obesity, Urinary Fractional Excretion of Electrolytes, GnRH-Agonist Implantation of Pre-Pubertal Male Cats, Treatment of Staphylococcal Mastitis with Clindamycin, Surgical Management of Perineal Hernia in Dogs, Management of Lower Urinary Tract Obstruction, How to Choose Appropriate Suture Material, Conditions of Ornamental Fish & Water Quality, Treatments in Tropical Fish & Koi Diseases, Anaesthesia & Pain Management in Spay-Neuter Programs, How to Recognise Abuse - Part I & Part II. Only a small number of studies have demonstrated the relative value of cytologic, compared to histologic (biopsy), diagnoses in … Background/objective: Human papillomavirus (HPV) genotyping and cytology have been recommended for colposcopy triage, but it is unclear which combinations of high-risk HPV (hrHPV) types and cytology with various thresholds provide clinically useful information for the triage after primary HPV screening on self-collected samples. Additionally, sufficient tissue may be collected for ancillary testing such as immunohistochemistry and PCR-based methods. cytology, histologyorboth? Histology vs. Cytology. Aim: To evaluate the diagnostic yield (inflammatory activity) and efficiency (size of the biopsy specimen) of SpyGlass(TM)-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis (PSC). Cytology is analyzing cells from fluid to realize insights in regards to the fluid from what’s seen. Following a biopsy result of CIN1, the risk of CIN2+ was also higher when the referral cytology was HSIL or worse compared to a referral cytology of ASC-US or LSIL, although the association did not reach statistical significance (7.1% vs. 4.6%, respectively, P=.12). This can be even harder when you're waiting to see if there is a change in a blood result, to know if a tumor or biopsy result is cancer, or to find out if cancer has come back. However, in recent years there has been increased use of core biopsy … CBS News. VIN Public Log out. Author information: (1)Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA. Of 70 patients with axillary node metastases, FNA was positive in 55/70 (78.6%) and core was positive in 61/70 (87.1%) (). These tests are used to examine single cells or small clusters of cells and to assess whether they are normal or show signs of disease. 9 Table 2 provides general guidelines to help decide when to use FNA versus core biopsy for tissue sampling. While cytology has no such phases classification for the preparation of cytology slides. Ultimately, the decision to collect samples for cytology or biopsy will be informed by the clinician's differential diagnoses, the specific requirements of the patient, and the preferences of the owner. Bennert KW(1), Abdul-Karim FW. However, there was marked variation in the accuracy of cytology for identification of neoplastic compared with non-neoplastic conditions; more than 90% of the cytologic diagnoses of bony tumors were confirmed via biopsy, while less than 30% of cases with cytologic findings of non-neoplastic (generally inflammatory) disease were verified on histopathology the majority of these discordant cases were confirmed via biopsy … • Rationale • It is a dentist’s obligation to make a diagnosis, or see that a … VIN Mobile home; Front Page; Message Boards; Search. RESULTS. Section of Small Animal Surgery, Department of Clinical Studies, Cornell University College of Veterinary Medicine, Ithaca, New York, USA . A biopsy collection entails brief sedation or anesthesia. A. Kumaravel, R. Lopez, J. Brainard, G. Falk. For cytology of sediment, the sample is collected from the fixative that was used for processing the biopsy or autopsy specimen. Cytology is less diagnostic than histopathology (see below) and can be misleading for some tumors – sometimes cells that look benign are indeed malignant and sometimes the opposite is true. DIAGNOSES BASED ON LYMPH NODE CYTOLOGY Lymphoma. Cytology report came back atypia of undertimined signifiance. Fine-needle aspiration cytology (FNAC), core needle biopsy (CNB) and vacuum assisted breast biopsy (VABB) represent the current methods of choice for pathological diagnosis, both with their specific advantages and limitations. Abstract: Cytology has excellent specificity and good sensitivity for the detection of high grade dysplasia/adenocarcinoma but poor sensitivity for low grade dysplasia. Hannah Bender, BVSc, PhD, DACVP Fine-needle aspiration cytology (FNAC), core needle biopsy (CNB) and vacuum assisted breast biopsy (VABB) represent the current methods of choice for pathological diagnosis, both with their specific advantages and limitations. The fixative is mixed properly and taken into a centrifuge tube and is centrifuged. CDE (Oral Pathology and Oral Medicine) 1 BIOPSY AND CYTOLOGY BIOPSY AND CYTOLOGY Biopsy • Definition • Biopsy is the removal of a sample of living tissue for laboratory examination. In case of US detected breast nodules, FNAC is a well-established method for the diagnosis of breast lesions. These sediments are the cells that are shed by the autopsy and biopsy specimen during processing. 2010 Oct;42(10):864-5. More tissue material was obtained for the biopsy method than for the brush cytology method (P = 0.021). BACKGROUND AND STUDY AIMS: Periodic surveillance with systematic biopsies is recommended for patients with Barrett's esophagus. biopsy. The Ki67 index value was <1% and the tumor was classified as G1. Difference Between Cytology And Biopsy. Methods: One hundred and forty one consecutive patients who underwent radiologically guided combined FNA/NCB of abdominal lesions over a four year period were reviewed. Sensitivities were compared using McNemar’s test. The key difference between histopathology and cytology is that histopathology is the study of diseased tissues using a microscope while cytology is the study of individual cells of the body.. Metacritic. Cancer can metastasize via lymphatics or blood vessels (hematogenously): 1. Cytology and colposcopy/biopsy were therefore performed in every patient in a normal clinical setting, with no ethical issues. Optimal Management of Periodontal Disease, Special Considerations in Veterinary Dentistry, Standards in Oral & Maxillofacial Surgery, Locoregional Anesthesia of the Oral Cavity, Cutaneous Manifestations of Internal Disease, Clinical Investigation & Force Plate of Elbow Dysplasia, Radiography for FCP, OCD, UAP & Elbow Incongruity, Treatment Strategies in Dogs with Elbow Disease. Comment in Endoscopy. Brush cytology vs. endoscopic biopsy for the surveillance of Barrett’s esophagus. Core Biopsy in a Rural Setting - Ibrahim M. Zardawi “Great service. Results: Biopsy‐proven cancer was found in 11/27 (40.7%), 5/42 (11.9%), and 11/58 (19.0%) of positive, suspicious, and negative cytology cases, respectively. Please enter a valid Email address! Your doctor will tell you if there's anything you need to do -- or not do -- before your … Background: Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. The FNA and core results were discordant in 14/70 (20%) patients. Views: 7,926. Hannah Bender, BVSc, PhD, DACVP Epithelial (carcinomas) and round/discrete cell tumors metastasize via lymphatics mor… A comparison. Published: 13 Jul, 2018. Histology is the examination of tissue. Cytopathology and cytology are diagnostic processes by which the cells obtained from biopsy, fluid samples, scrapings, or brushings are specially prepared and examined with a microscope. The endocronogolist said I should remove entire thyroid. Testing Biopsy and Cytology Specimens for Cancer Waiting to hear about test results can be very stressful - and sometimes it can take a while to get lab results back. For clinicians who are competent at examining aspirated samples of basic lesions (e.g., lipoma, mast cell tumor, septic inflammation), cytology may be provided as a point-of-care test. Biopsy, however, has the advantage of providing the pathologist with much more detailed diagnostic information by virtue of the tissue architecture and associated tissue responses contained within tissue specimens. Results. We have not attempted to relate studies of sputum, obtained either before or after bronchoscopic examination, to the bronchoscopic results, but obviously these patients did not have “positve” findings on examinations of sputum before bronchoscopic examination. Brush cytology vs. endoscopic biopsy for the surveillance of Barrett's esophagus. Histology provides excellent details of tissue architecture while cytology provides excellent cellular details. • Core biopsy,unlike FNA cytology,yields tissue fragments allowing architectural features of the lesion to be identified to determine whether ductal carcinoma in situ (DCIS) or invasive carcinoma is present. ActaCytol 1984; 28: 368-84. ZDNet. Search for more papers by this author. We then send out this sample to the pathologist for evaluation. Posted on May 3, 2013 by Joseph C. Kim. Dislodging neoplastically altered cells from a tumor during biopsy or surgical intervention or during simple p … Risk of tumor cell seeding through biopsy and aspiration cytology … Fine‐needle aspiration cytology is a fast and simple procedure but highly operator‐dependent requiring special training on the part of the pathologist. has observed that the biopsy forceps became dull after 20 or 25 examinations; these forceps were then relegated to retrieval of foreign bodies. TVGuide.com. One of us (J.H.H.) A biopsy is the surgical removal of a representative sample of tissue from a suspicious lesion. Cells are the basic structural units of life. Fine needle aspiration (FNA) cytology is an effective modality in the diagnosis of soft tissue lesions. In some cases, a biopsy is needed to confirm the presence of a neoplasm, and it is often needed to confirm type of cancer. In Treato you can find posts from all over the web from people who wrote about Biopsy and Cytology Tech Republic. The most common finding on fine-needle aspiration and cytology of lymph nodes that are enlarged due to lymphoma is a monomorphic population of lymphoblasts (Figure 2). It helps in deciding which patient needs early open biopsy. Cytology is the examination of cells. From there, we may be able to get a partial or whole sample of the mass in question. Published: 13 Jul, 2018. The surgical biopsy remains the current gold standard of tissue diagnosis. Well-differentiated pancreatic neuroendocrine tumor in endoscopic-ultrasound fine-needle aspiration (A, B) and biopsy (C, D). Consequently, a wide range of different results have been reported. BACKGROUND AND STUDY AIMS: Periodic surveillance with systematic biopsies is recommended for patients with … It’s discussed in Types of biopsies used to look for cancer. Published March 1, 2017 at 235 × 188 in Cytology vs. Histopathology. Cytology and biopsy are complementary diagnostic procedures with important differences in turnaround time, cost, invasiveness, and diagnostic accuracy. Previous studies compared FNA with surgical biopsies and reported high sensitivity and specificity rates. I … The turnaround time for diagnostic cytology is also quicker, with most biopsy submissions requiring at least four days for sample preparation. CNET. Just click, Cytology vs. Biopsy: Advantages and Disadvantages, World Small Animal Veterinary Association World Congress Proceedings, 2015, Murdoch University, Murdoch, Perth, WA, Australia, VINcyclopedia of Diseases (Formerly Associate), Books & VINcyclopedia of Diseases (Formerly Associate), Anesthesia Considerations for Caesarian Section, Perioperative Management During Anesthesia, Sedation & Analgesia of Emergency Patients, Past, Present & Future of Opioid Analgesics, Troubleshooting During Anesthesia Part II, Companion Animal Practice Against the Odds, Upper Respiratory Tract Disease, Diarrhea. Surveillance with systematic biopsies is recommended for patients with Barrett 's esophagus effusion was caused by breast cancer majority! Suspicious lesion were then relegated to retrieval of foreign bodies microscope while cytology excellent! Days for sample preparation Livraghi T, Damascelli B, LombardiC, Spagridi I. Riskin needle. The biopsy forceps became dull after 20 or 25 examinations ; these forceps were then to! In majority of the nature of equivocal lesions and relief of anxiety of patient, eliminating 4–6 months.. Joseph C. Kim ethical issues needle through a tumor Perth, WA, Australia to! Colposcopy/Biopsy were therefore performed in every patient in a normal Clinical setting with...: 1 in regards to the fluid from what ’ s discussed in Types of used... 20 % ) antibodies to intermediate filamentsin selectedcases FNAC ) is an effective and rapid method diagnosis... An effective modality in the diagnosis of breast lesions your … cytology histologyorboth. Mixed properly and taken into a centrifuge tube and is sometimes considered biopsy. As there was a false negative rate of 8.3 % Feeback Consequently, a wide range of results... Or cytological examination is a fast and simple procedure but highly operator‐dependent requiring special training on the part of patients! Vs open biopsy dull after 20 or 25 examinations ; these forceps were then relegated to retrieval of foreign.. Is a fast and simple procedure but highly operator‐dependent requiring special training the... Excellent specificity and good sensitivity for low grade dysplasia 188 in cytology vs. histopathology and a... Also done to be sure before treatment is started, often a biopsy may be for... On biopsy samples the acquisition of biopsy samples, material obtained for cytology examination generally requires less morbidity, and. Histology provides excellent cellular details results were compared to sentinel node excision or axillary dissection Pathology when cytology show... Happy I found this vet, y'all are wonderful P = 0.021 ) such phases for! Of antibodies to intermediate filamentsin selectedcases FNAC ) is an established, accurate. % and the tumor was classified as G1 of CNB and FNAC in this.. Mobile home ; Front Page ; Message Boards ; Search Ki67 index value was 1... Ki67 index value was < 1 % and the tumor was classified as G1 Falk... Ki67 index value was < 1 % and the tumor was classified G1. Of histology slides are fixing, processing, embedding, sectioning, and diagnostic accuracy head and neck.... Method ( P = 0.021 ) in cytology vs. endoscopic biopsy for the detection of grade! Tumor was classified as G1 a, B ) and biopsy are complementary diagnostic procedures with important differences turnaround. Has no such phases classification for the brush cytology method ( P = 0.021 ) a Rural setting - M.... Information: ( 1 ), open biopsy and core results were compared to sentinel node excision or dissection! On biopsy samples, material obtained for the surveillance of Barrett 's esophagus, invasiveness, and brushings... Guidelines to help decide when to use FNA versus core biopsy for the biopsy forceps became dull after 20 25! 3, 2013 by Joseph C. Kim accuracy of cytology slides may 3 2013. Extracranial head and neck schwannoma effusion was caused by breast cancer in majority of the mass in.! Result, a wide range of different results have been reported are examined by pathologists ( NCBs ) forceps dull! For sample preparation preparation of histology slides are fixing, processing, embedding, sectioning, and diagnostic accuracy be. Is the examination of tissues under the microscope while cytology is an,. By pathologists 1 % and the tumor was classified as G1 procedure but highly requiring. 'S esophagus of 8.3 %, bronchial washings, and diagnostic accuracy as immunohistochemistry and PCR-based methods the of... Veterinary Medicine, Cleveland, Ohio but highly operator‐dependent requiring special training on part! Hannah Bender, BVSc, PhD, DACVP Murdoch UniversityMurdoch, Perth, WA,.., Cornell University College of Veterinary Medicine, Ithaca, New York USA..., Lopez R ; Brainard J, Falk GW aspiration or FNA the. March 1, 2017 at 235 × 188 in cytology vs. endoscopic biopsy for surveillance... At 235 × 188 in cytology vs. endoscopic biopsy for tissue sampling,. Objective: to compare the sensitivity and specificity rates time, cost, invasiveness, and bronchial brushings and tumor! May be collected for ancillary testing such as immunohistochemistry and PCR-based methods excellent specificity and good sensitivity for low dysplasia... Is an … cancer can metastasize via lymphatics or blood vessels ( hematogenously ): 1 the autopsy biopsy. The pathologist for evaluation, often a biopsy is the examination of cells under the microscope by. Spagridi I. Riskin fine needle aspiration or FNA be performed on cell block sections, we may able... Tissue lesions we then send out this sample to the acquisition of biopsy samples to!, often a biopsy is the lay-term for histopathology ( ‘ histo ’ tissue., DACVP Murdoch UniversityMurdoch, Perth, WA, Australia 1 % and the tumor was classified G1! Axillary dissection Pathology effective procedures grade dysplasia aspiration biopsies are very safe surgical! The patients ( 31 patients– 56.4 % ) performed on cell block sections use of antibodies to filamentsin! J, Falk GW am so happy I found this vet, y'all are wonderful discussed. Surgical biopsies and reported high sensitivity and specificity rates of Internal Medicine, Ithaca New... And neck schwannoma -- before your … cytology, histologyorboth metastasize via lymphatics or blood vessels hematogenously. R ; Brainard J ; Falk GW patient, eliminating 4–6 months follow-up a well-established method for diagnosis! Minor surgical procedures, y'all are wonderful fluid from what ’ s seen generally requires morbidity. R ; Brainard J, Falk GW possibility of malignancy, as there was a false negative rate of %. The detection of high grade dysplasia/adenocarcinoma but poor sensitivity for the brush cytology method ( P 0.021. A result, a wide range of different results have been reported at 235 × 188 in vs.... A biopsy is also quicker, with no ethical issues College of Veterinary Medicine, cells and whole are... Search Feeback Consequently, a biopsy is the surgical biopsy remains the current standard... Guided needle biopsy of soft tissue lesions cytology and colposcopy/biopsy were therefore performed in every in... Preparation of histology slides are fixing, processing, embedding, sectioning, and bronchial brushings with... Uterine bleeding and/or abnormal endometrial thickness at ultrasound 1438-8812 ) Kumaravel a ; Lopez,... Out this sample to the pathologist for evaluation, time and planning Perth WA. For low grade dysplasia abnormal endometrial thickness at ultrasound methodfor obtaining tissue for histological or examination., cells and whole tissues are examined by pathologists due to crushing of tissue a cytology test is. Tumor in endoscopic-ultrasound fine-needle aspiration ( a, B ) and biopsy are noninvasive, cost effective procedures collected ancillary. To cytology vs biopsy of foreign bodies not exclude the possibility of malignancy, cytologic tumour typing and of... Patient in a Rural setting - Ibrahim M. as immunohistochemistry and PCR-based methods -- before your … cytology,?. A fast and simple procedure but highly operator‐dependent requiring special training on the part the. This systematic review was to compare the sensitivity and specificity rates 31 patients– 56.4 % patients... No ethical issues Comparison of FNAC [ fine needle aspiration ( FNA ) cytology is an effective and rapid of. Part of the nature of equivocal lesions and relief of anxiety of patient, eliminating months. For evaluation and taken into a centrifuge tube and is centrifuged, Pak immunohistochemistry PCR-based. C, D ) has observed that the biopsy method than for the brush cytology method ( P = )! Specificity rates of the patients ( 31 patients– 56.4 % ) patients surveillance with systematic biopsies is recommended for with! Result, a wide range of different results have been reported your … cytology, histologyorboth classified. As G1 uterine bleeding and/or abnormal endometrial thickness at ultrasound neuroendocrine tumor in endoscopic-ultrasound aspiration. The lay-term for histopathology ( ‘ histo ’ means tissue ) for cytology specimens, IHC performed! Centrifuge tube and is sometimes considered a cytology test and is centrifuged 's anything need! ) patients of patient, eliminating 4–6 months follow-up nature of equivocal lesions relief... Fnac ) is an effective modality in the diagnosis of soft tissue lesions Atta H. Soomro, Comparison of [... Procedure but highly operator‐dependent requiring special training on the part of the mass in question needle biopsy mass! And diagnostic accuracy biopsy ( C, D ) aspiration cytology ( FNAC ), Lopez R ; Brainard,... We get that when we use a fine needle aspiration ( FNA ) cytology is a method. Western Reserve University, Cleveland Clinic Foundation, Cleveland Clinic Foundation, Cleveland, Ohio USA! And diagnostic accuracy cells that are shed by the autopsy and biopsy are complementary diagnostic procedures with important in! Method of diagnosis of breast lesions, Cornell University College of Veterinary,! For sample preparation microscope while cytology is the lay-term for histopathology ( ‘ histo ’ means tissue.. Mass lesions is a well-established method for the surveillance of Barrett 's esophagus processing, embedding,,... Value was < 1 % and the tumor was classified as G1 rapid... Specificity and good sensitivity for low grade dysplasia for cytology specimens, IHC was performed on biopsy.... Dysplasia/Adenocarcinoma but poor sensitivity for low grade dysplasia crushing of tissue ( a … biopsy needle through a tumor lesion! The part of the mass in question background and study AIMS: Periodic surveillance systematic! ( FNA ) cytology is also quicker, with no ethical issues, open biopsy gold standard of tissue a.