common laboratory animals pdf

x��][�$�q��>Zy�+˖bgV��9��y'_��XX Q��A)��T�V�fuϬ,ـDM�R,?֍~��wq1��/��_A�xRnI��J-�b<=��z�a��>�?_}{�o�7.0��6��P�� A-quޜ߾�"��_Ҫ��14IF�t�E�:��ZT��C��{H��:�3k��[�9�Ca�-��z�.��7�&��G�.ںp~��}G��:N>��^CA�:��]6W��Z��B-c:��. From: Lab Animal. Source: Adapted from Formulary for Laboratory Animals, Hawk, Leary, and Morris 2005. 0000002783 00000 n Fowl Plague (OIE Reference Laboratory for Avian Influenza; FAO Reference Centre for influenza in animals and Newcastle disease) Infection with Bonamia exitiosa (NRLs for Mollusc Diseases) Infection with Bonamia ostreae (NRLs for Mollusc Diseases) • Research animals must be used in a responsible manner. Monitoring 7. 0000007164 00000 n 0000007266 00000 n 0000001354 00000 n 0000001375 00000 n ILAR News 34(4):51-526. Blood Collection Sites and Methods The following are frequently used sites for survival blood sampling from common laboratory animal species. endobj Guide for the Care and Use of Laboratory Animals (1996 ed. �]�h��L�X�"�/p��a��shR�L��'�&�úD�. These drugs are speciﬁcally formulated and supplied with information on in-dications, dose, dose frequency, routes of administration, and safety. endobj 0000003675 00000 n Blood sample collection in small laboratory animals, J Pharmacol Pharmacother, 2010 Jul-Dec; 1(2); 87-93. techniques into the field of laboratory animal anaesthesia. 0000008239 00000 n Read chapter DISEASES OF LABORATORY ANIMALS: Handbook of Laboratory Animals... Login Register Cart Help. Laboratory/Research Skills for Science Resume List of skills to assist with resumes, cover letters and interviews Animal Care Handle and restrain Weigh animals Breed various species Clean cages Administer injections Prepare special diets Anesthetize Maintain and evaluate animal records Prepare for sterile surgical procedures Laboratory Animals: All Issues - Laboratory Animals. Laboratory animals are animals used for research purposes for developing and testing medicines and vaccines for humans and other animals. Blood may be collected from animals which are to survive the procedure or at sacrifice as a terminal event. Dogs and cats must be obtained from designated breeding establishments. The aim was to refine administration procedures and improve animal welfare and science. 0000006282 00000 n trailer << /Size 88 /Info 58 0 R /Root 60 0 R /Prev 78502 /ID[] >> startxref 0 %%EOF 60 0 obj << /Type /Catalog /Pages 57 0 R >> endobj 86 0 obj << /S 202 /T 290 /Filter /FlateDecode /Length 87 0 R >> stream 2000;29(5):32-37. A zoonotic disease is any disease that may be transmitted from an animal to a human under natural conditions. The prevention or minimization of animal pain, distress, or discomfort by the proper use of tranquilizers, anesthetics, and analgesics is scientifically and ethically essential to the humane care, use, and treatment of research animals. E.g. Sources of animals Under the 1986 Act the following commonly-used species that are bred for laboratory use: mouse, rat, guinea-pig, hamster, rabbit and primate must be obtained from designated breeding or supply establishments. 86 87. Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study.This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Animal welfare is attracting increasing interest worldwide, but particularly from those in developed countries, who now have the knowledge and resources to be able to offer the best management systems for their farm animals, as well as potentially being able to offer plentiful resources for companion, zoo and laboratory animals. endobj %PDF-1.2 %�� the animal is anemic (below the normal PCV range for the species), or if the hemoglobin concentration is less than 10 g/dL, it is not safe to remove the volumes of blood listed above. Laboratory Animals. Email: jbalcombe@pcrm.org. • Scientifically-valid research designed to reduce, refine or replace the need for laboratory animals is encouraged. The domestic mouse, Mus musculus and related subspecies (see Mice and Rats as Laboratory Animals), is popular as a mammalian research model because of its small size, adaptability, docility, low husbandry costs, fecundity, well-defined health and genetic backgrounds, and relative ease of genetic manipulation.The development of genetic engineering techniques of inserting … 0000001842 00000 n 2020 2020 Volume 54 Issue 6, Current Issue December 2020 , pp. One of the most common health risks in the research animal setting is allergic reaction to lab animals. Analgesics 5. 59 0 obj << /Linearized 1 /O 61 /H [ 982 393 ] /L 79810 /E 10068 /N 9 /T 78512 >> endobj xref 59 29 0000000016 00000 n 5 0 obj 35, 1-41. Definition, nomenclature, and conservation of rat strains. The 8th edition of the Guide for the Care and Use of Laboratory Animals, released in 2011, at 220 pages represented a 76% increase in information, guidance, and prescribed action from the content of the 7th edition (1996). {.s��|��-2��LPȋ��͛�ο)� Wz�,�{a��"��M�ɿ��q}��b�͞ʬ.�l7��&��)�!z�H�tWca��"�gQj��7< endstream endobj 69 0 obj 716 endobj 70 0 obj << /Filter /FlateDecode /Length 69 0 R >> stream ,c��s��L�S]�=�� Ib endstream endobj 87 0 obj 280 endobj 61 0 obj << /Type /Page /Parent 57 0 R /Resources 62 0 R /Contents [ 68 0 R 70 0 R 72 0 R 74 0 R 76 0 R 80 0 R 82 0 R 84 0 R ] /Thumb 36 0 R /MediaBox [ 0 0 598 846 ] /CropBox [ 0 0 598 846 ] /Rotate 0 >> endobj 62 0 obj << /ProcSet [ /PDF /Text ] /Font << /F2 77 0 R /F9 63 0 R /F10 64 0 R /F11 66 0 R >> /ExtGState << /GS1 85 0 R >> >> endobj 63 0 obj << /Type /Font /Subtype /Type1 /Name /F9 /Encoding 65 0 R /BaseFont /Times-Roman >> endobj 64 0 obj << /Type /Font /Subtype /Type1 /Name /F10 /Encoding 65 0 R /BaseFont /Times-Italic >> endobj 65 0 obj << /Type /Encoding /Differences [ 1 /Agrave /Egrave /Igrave /Ograve /Ugrave /agrave /egrave /igrave /ograve 11 /Aacute /Eacute /Iacute /Oacute /Uacute /Yacute /aacute /eacute /iacute /oacute /uacute /yacute /Acircumflex /Ecircumflex /Icircumflex 27 /Ucircumflex /acircumflex /ecircumflex /icircumflex /ocircumflex 128 /ucircumflex /Atilde /Ntilde /Otilde /atilde /ntilde /otilde /Adieresis /Edieresis /Idieresis /Odieresis /Udieresis /Ydieresis /adieresis /edieresis /idieresis /odieresis /udieresis /ydieresis /Aring /aring /Ccedilla /ccedilla /Scaron /Zcaron /scaron /zcaron /Eth /eth /Thorn /thorn /Ocircumflex /minus 209 /trademark /copyright /logicalnot /registered 214 /brokenbar /degree /plusminus /twosuperior /threesuperior /mu /onesuperior /onequarter /onehalf /threequarters /multiply ] >> endobj 66 0 obj << /Type /Font /Subtype /Type1 /Name /F11 /Encoding 65 0 R /BaseFont /Times-Bold >> endobj 67 0 obj 686 endobj 68 0 obj << /Filter /FlateDecode /Length 67 0 R >> stream animals, killing animals and of those responsible for the design of procedures and projects. 0000000982 00000 n Table of Contents 1. In many clinical situations, laboratory animal veterinarians do not endobj List of Issues View. Training 3. *{~��ƅ �m��:?R��n��@��8�� >��+l��aq?��}��?��+�D�W��W֙�'��^~�@�,|�b�X�,��\=h��d�C��_{�b�4�S9��E��1�[�F�� Animal Care and Use Committee Page . 525-607 Issue 5, October 2020 , pp. Laboratory Animals 1. <> 0000008218 00000 n 0000009824 00000 n <>stream Animal Care and Use Program University of California, Berkeley . �y�%�$^�M��A�B��]*�L�;G��v��)`�셗"��s��82��5�Y�XGVP�I?8��zZ�yY߻9n�e��71�7U;��W-�Cm�Fmʳvm��(�{0�Xi�� ;~]|>g�*>)��O�_�O��ԋDf�4PY 1ka��ڏ�{RXB�&�ta�-k�蓶�Cȹ �!l�n*΍��=U? • Guidelines for anesthesia and analgesia in laboratory animals; University of California. Common laboratory animal MARTIN JACOB 1ST YR M.PHARM Department of pharmacology Shree devi college of pharmacy manglore 2. 4 0 obj 0000002911 00000 n 0000000927 00000 n The international journal of laboratory animal science, technology, welfare and medicine, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the care and use of animals in biomedical research. 0000004511 00000 n Laboratory animals have been successfully trained to perform various husbandry or clinical tasks, including moving to a new part of an enclosure (Veeder et al., 2009), presenting a body part for an injection or another procedure (Priest, 1991; From: Animal Models for the Study of Human Disease (Second Edition), 2017. use in common laboratory species used in toxicity studies required by regulatory authorities; (ii) to provide consensus dosage levels for routine use that represent good practice in terms of ani-mal welfare and practicality; (iii) to produce a guide to dosage levels representing the upper limit of common practice, which leaves A report of the Institute of Laboratory Animal Resources Committee on Rat Nomenclature. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses … 0000005412 00000 n animals in general) Ôbedding and nesting materials should be provided, unless it is clearly inappropriateÕ (para 3.60). NRC (National Research Council). ;��GD�� ]�P�;��/��ַ�J��)�Ojb2F�5�� 1¼��0��ap�n��Sp��F((��&��}�E�U�� ҸirW�ƣy6�b��,��-sgJg7o��ge]. laboratory animals according to the animal welfare and ethical norms. These usually have been preserved by embalming, and one or more parts of the vas-cular system have been injected with a colored material to facilitate identiﬁ cation of the vessels. Proper handling of laboratory animals goes a along way to ensure reproducible results are obtained. Browse by year. In addition, an estimated 10% of workers will eventually develop occupation-related asthma. Study in a typical gross anatomy laboratory is based primarily on dissection of animal cadav-ers. This handbook attempts to provide a basic guide to anaesthesia for research workers and animal technicians. 0000007325 00000 n <> Recordkeeping 8. Laboratory Animals (2006) 40 , 217 235 REVIEW ARTICLE Correspondence: J P Balcombe. 0000007346 00000 n Wildlife species used as research s… Handling of laboratory animals and ethics 10th to 11th Novomber, 2016 Laboratory Animal Resources Section ICAR- Indian Veterinary Research Institute Izatnagar, Bareilly-243 122(U.P), India Training Program on SOT Animals in Research Public Policy Statement 1999 Research involving laboratory animals is necessary to ensure and enhance human and animal health and Background 2. Best Practices 6. April 1967 - December 2020 Select an issue. 6 0 obj H��TMS�0�{��AG��U}�:��4��2�� :6Mb��we%��d��C�+�{��vu��c�J��K�p�26!L�t�;d�'D .�_8_: �k|6�6��;�b)ÿ�7��t��|8��n�3G�芙��U��~F\�½��ʙ��]N�ZǲU�!�2 y�P�Y�>n�V'��I�"�U+�'\��>� 攲I�i�ҷ�? Web: www.pcrm.org Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF. 0000006303 00000 n Laboratory Animals. The paper covered the most commonly used routes in common laboratory species. 0000001951 00000 n %�� Laboratory Animals: Regulations and Recommendations for the Care and Use of Animals in Research, Second Edition, is the only publication to offer a global compilation of standards on the care, welfare and use of animals in research.The book provides updated information that will be of great interest to professionals across laboratory animal science and biomedical research. Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals 3rd Edition continues as the most comprehensive reference on in vivo animal studies. It is organized into five chapters that cover the subject areas of 1) key defining concepts, including applicability, a brief review of the ethical principles in the … The Welfare of Laboratory Animals PDF.. Animals used for laboratory research or teaching purposes at the University of Montana (UM) include mice, rats, guinea pigs, rabbits, hamsters, and birds. <> INTRODUCTION Selection of animal model Use of an animal phylogenetically closer to man Use of an animal in which the process under investigation is as close as possible 2. The focus 0000001735 00000 n 0000009117 00000 n Standardized nomenclature for transgenic animals. 1. of . It is the responsibility of Principal Investigator (PI) to educate their staff on zoonotic diseases of the animals that they are using in their research or teaching activities. Healthy and well being of lab. Provides information on blood sampling techniques for many common species to help laboratory staff remove blood from animals in the most humane and efficient way. • Guidelines on anesthesia and analgesia in laboratory animals, University of South Florida, 2009; 1-20. 0000003696 00000 n 0000001597 00000 n A Council of Europe review of housing standards Accepted 28 October 2005 r Laboratory Animals Ltd. However, there is a growing body of literature on environmental-enrichment strategies for many of the common laboratory animal species, and the Guide (NRC 1996a) provides an impetus for institutions to evaluate and incorporate enrichment measures into their animal care and use program for all species where appropriate. If you need to print pages from this book, we recommend downloading it as a PDF. <> 0000002890 00000 n The Clinical Chemistry of Laboratory Animals 3rd Edition PDF. Section 495 of … %PDF-1.4 2 0 obj GUIDELINES FOR ANESTHESIA AND ANALGESIA IN LABORATORY ANIMALS. Anesthetics 4. <>/Rotate 90/Parent 5 0 R/Annots[]/MediaBox[0 0 612 792]/Contents 6 0 R/Type/Page>> H�}T�r�0�{��;�*��#M�qRצ]䱐A1j ��I��-��#JC�*US��~/�� ًC��rp� I�� ?�F�R֖��C�j1�Q[{��RT�+a2�H8��r�}1$�N� F ��0y(�VSm�&1��5��[� }��t�1 �r�@��ۆ��:��p3Ȭ8�(��jT=��?��#�C�5��z�ޙM��4��@-. 1 0 obj H�c```�k��&J]`p��P}j��`qfE�Z��ƆY��zY\y��H�~Sq�Y�� ޭ2SȽ(��(��pF��R끖� �:B��ԀFa��@&�1�� (�X\@�Y�� .I��A,"��!밆�qjc�s��x]�=�:8L xS�f2�T?��)(��ƴ�uZ�K�%�XH� ]�Hs�8L� 9. Note: If the amount of blood volume removed is 7.5% of total blood volume, allow 1 week recovery; if amount removed is 10%, allow 2 weeks recovery; if amount removed is 15%, allow 4 weeks recovery. VETERINARIANS TREATING common farm and companion species can use a wide range of drugs with regulatory approval. laboratory animals 1. laboratory animals mehul ramanlal chorawala department of pharmacology k. b. institute of pharmaceutical education and research a constituent college of kadi sarva vishwavidyalaya gh-6, sector-23 gandhinagar-382023, gujarat 2. Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. ), and the Animal Welfare Act (Public Law 89-544). It is not intended to be a comprehensive text on animal anaesthesia, but concentrates on those areas that are of greatest practical importance when anaesthetizing laboratory animals. 0000005391 00000 n Collection of blood from laboratory animals is frequently necessary for a variety of experimental uses including determination of pharmacokinetics, antibody production, clinical pathology evaluation, etc. BIOLOGICAL NAMES • Genus: which have common characteristics and which can be divided into subordinate kinds. 0000004490 00000 n The common education and training framework facilitates and assures the competence of all persons involved in the use, care and breeding of animals for scientific procedures, and assists the free movement of personnel. About this journal. This report was drawn from the scientific community from industry, academia, and animal welfare organizations. Blood Sampling in Sheep ( pdf … 1992b. 0000009138 00000 n 5 Last Revised December 20, 2016. OLAW and APHIS: Common Areas of Noncompliance STEPHEN POTKAY, VMD AND WILLIAM R. DEHAVEN, DVM OLAW’s Compliance Oversight: Noncompliance with PHS Policy Stephen Potkay, VMD The welfare of animals used in research has been a concern of the Public Health Service (PHS) since the mid-1900s1. Common Sites for Blood Collection: Introduction Laboratory animals are used for different studies It may include bioassay, preclinical studies etc. It is estimated that anywhere from 10% to 44% of animal care workers will develop allergic symptoms to the animals. 3 0 obj endobj 44 % of workers will eventually develop occupation-related asthma in a responsible manner disease that may be transmitted an! Genus: which have common characteristics and which can be divided into subordinate kinds the! Into subordinate kinds animal to a human under natural conditions welfare and science the need for laboratory animals goes along. 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