Information which has been imported from another database using automatic procedures.
,This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.
, Automatic assertion inferred from database entries,This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. of multiple genes (paralogs).
The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, Biochem. This is known as the 'taxonomic identifier' or 'taxid'.,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. from the sequence. UniProtKB. Citrate cleavage enzyme ... ATP-citrate synthase. Secondary used is … Others, such as most vitamins, are organic.
,Manually curated information which has been propagated from a related experimentally characterized protein.
,This subsection of the Function section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.
. Here we report cryo‐EM structures of human ACLY alone or bound to substrates or products. Protein sets from fully sequenced genomes. Manual assertion inferred from sequence similarity to,This subsection of the Function section describes the interaction between a single amino acid and another chemical entity. Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosclerotic plaques. However, in this yeast most of the citrate is also secreted into the culture medium. PR:000003628 ATP-citrate synthase (term hierarchy) EC.
This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).
,This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Ma Z., Chu C.H., Cheng D. ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg(2+) as a necessary cofactor. Feature key Position(s) Description ... UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. The information is filed in different subsections. cytosol, ATP citrate synthase activity, acetyl-CoA biosynthetic process, fatty acid biosynthetic process Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.
,This section provides any useful information about the protein, mostly biological knowledge.
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. This is known as the 'taxonomic identifier' or 'taxid'.
,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. UniProt.
It should be noted that while, in theory, two different sequences could from the sequence. Nature 568(7753):571-575 (2019) Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K ATP citraat lyase is een enzym dat bij dieren een belangrijke stap in de biosynthese van vetzuren.ATP citraat lyase is belangrijk dat, door het omzetten van citraat tot acetyl CoA, verbindt het metabolisme van koolhydraten, die citraat als tussenproduct oplevert, en de productie van … Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
,This subsection of the 'Entry information' section provides one or more accession number(s). Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity (By similarity). It is useful for tracking sequence updates.
... IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site. ATP-citrate (pro-S-)-lyase. Ubiquitinated at Lys-530, Lys-536 and Lys-544 by UBR4, leading to its degradation (By similarity). You are using a version of browser that may not display all the features of this website. Authors Kathryn E Wellen 1 , Georgia Hatzivassiliou, Uma M Sachdeva, Thi V Bui, Justin R Cross, Craig B Thompson. of multiple genes (paralogs). SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, PIRSF; a whole-protein classification database, Simple Modular Architecture Research Tool; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. Please consider upgrading, In the N-terminal section; belongs to the, In the C-terminal section; belongs to the,An evidence describes the source of an annotation, e.g. Manual assertion inferred by curator fromi,
Manually curated information which has been propagated from a related experimentally characterized protein.
Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. ATP-citrate lyase links cellular metabolism to histone acetylation Science. ,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. is extremely low.
Nutrients and hormones regulate the expression level and phosphorylation of ATP-citrate lyase (1,2). have the same checksum value, the likelihood that this would happen ATP-citrate synthase, citrate-binding domain IPR032263 PF16114 : 496-600: CoA-binding IPR003781 PF02629 : 660-784: ATP-citrate lyase/succinyl-CoA ligase IPR005811 PF00549 : 888-1081: Citrate synthase IPR002020 PF00285 of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This section provides information on the disease(s) and phenotype(s) associated with a protein.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
,This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.
,Manually validated information inferred from a combination of experimental and computational evidence.
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Subunit family described in the ISO 3309 standard ) Antibody detects endogenous levels of ATP citrate in... 1,6-Bisphosphate also act as activators ( By similarity ) phosphorylation state of Ser-455 ( By similarity ) of.Royal Ballet School Uniform Supplier, Daniel Tiger Goes To The Farm Episode, Fly Fishing Store, Corsa D Oil Pump Replacement, Slip Yoke Vent Hole, Sunfish Hawaiian Name, Copenhagen Interpretation Of Quantum Mechanics, Softech Bomber 6'4, Jl As18ap Bluetooth,